Document cayugacounty_gov_doc_6eafe9bdd7

JAVMA • Vol 248 • No. 5 • March 1, 2016 505 R abies is a fatal viral zoonosis and serious public health problem.1 All mammals are believed to be susceptible to the disease, and for the purposes of this document, use of the term animal refers to mam- mals. The disease is an acute, progressive encephali- tis caused by viruses in the genus Lyssavirus.2 Rabies virus is the most important lyssavirus globally. In the United States, multiple rabies virus variants are main- tained in wild mammalian reservoir populations such as raccoons, skunks, foxes, and bats. Although the Unit- ed States has been declared free from transmission of canine rabies virus variants, there is always a risk of reintroduction of these variants.3–7 The rabies virus is usually transmitted from ani- mal to animal through bites. The incubation period is highly variable. In domestic animals, it is generally 3 to 12 weeks, but can range from several days to months, rarely exceeding 6 months.8 Rabies is communicable during the period of salivary shedding of rabies virus. Experimental and historic evidence documents that dogs, cats, and ferrets shed the virus for a few days prior to the onset of clinical signs and during illness. Clinical signs of rabies are variable and include inap- Compendium of Animal Rabies Prevention and Control, 2016 National Association of State Public Health Veterinarians Compendium of Animal Rabies Prevention and Control Committee Catherine M. Brown dvm, msc, mph (Co-Chair) Sally Slavinski dvm, mph (Co-Chair) Paul Ettestad dvm, ms Tom J. Sidwa dvm, mph Faye E. Sorhage vmd, mph From the Massachusetts Department of Public Health, 305 South St, Jamaica Plain, MA 02130 (Brown); the New York City Department of Health and Mental Hygiene, 2 Gotham Center, CN# 22A, 42-09 28th St, Queens, NY 11101 (Slavinski); the New Mexico Department of Health, 1190 St Francis Dr, Room N-1350, Santa Fe, NM 87502 (Ettestad); and the Texas Department of State Health Services, PO Box 149347, MC 1956, Austin, TX 78714 (Sidwa). Consultants to the Committee: Jesse Blanton, PhD (CDC, 1600 Clifton Rd, Mailstop G-33, Atlanta, GA 30333); Richard B. Chipman, MS, MBA (USDA APHIS Wildlife Services, 59 Chenell Dr, Ste 2, Concord, NH 03301); Rolan D. Davis, MS (Kansas State University, Room 1016 Research Park, Manhattan, KS 66506); Cathleen A. Hanlon, VMD, PhD (Retired); Jamie McAloon Lampman (McKamey Animal Center, 4500 N Access Rd, Chattanooga, TN 37415 [representing the National Animal Care and Control Association]); Joanne L. Maki, DVM, PhD (Merial a Sanofi Co, 115 Trans Tech Dr, Athens, GA 30601 [representing the Animal Health Institute]); Michael C. Moore, DVM, MPH (Kansas State University, Room 1016 Research Park, Manhattan, KS 66506); Jim Powell, MS (Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706 [representing the Association of Public Health Laboratories]); Charles E. Rupprecht, VMD, PhD (Wistar Institute of Anatomy and Biology, 3601 Spruce St, Philadelphia, PA 19104); Geetha B. Srinivas, DVM, PhD (USDA Center for Veterinary Biologics, 1920 Dayton Ave, Ames, IA 50010); Nick Striegel, DVM, MPH (Colorado Department of Agriculture, 305 Interlocken Pkwy, Broomfield, CO 80021); and Burton W. Wilcke Jr, PhD (University of Vermont, 302 Rowell Building, Burlington, VT 05405 [representing the American Public Health Association]). Endorsed by the AVMA, American Public Health Association, Association of Public Health Laboratories, Council of State and Territorial Epidemiologists, and National Animal Care and Control Association. This article has not undergone peer review. Address correspondence to Dr. Brown ([EMAIL REDACTED]). petance, cranial nerve deficits, abnormal behavior, ataxia, paralysis, altered vocalization, and seizures. Progression to death is rapid. There are cur- rently no known effective rabies antiviral drugs. The recommendations in this compendium serve as a basis for animal rabies prevention and control pro- grams throughout the United States and facilitate stan- dardization of procedures among jurisdictions, there- by contributing to an effective national rabies control program. The compendium is reviewed and revised as necessary, with the most current version replacing all previous versions. These recommendations do not supersede state and local laws or requirements. Prin- ciples of rabies prevention and control are detailed in Part I, and recommendations for parenteral vaccina- tion procedures are presented in Part II. All animal ra- bies vaccines licensed by the USDA and marketed in the United States are listed and described in Appendix 1, and contact information for manufacturers of these vaccines is provided in Appendix 2. Modifications of note in this updated version of the compendium, compared with the previous ver- sion,9 include clarification of language, explicit en- Public Veterinary Medicine: Public Health ---PAGE BREAK--- 506 JAVMA • Vol 248 • No. 5 • March 1, 2016 couragement of an interdisciplinary approach to ra- bies control, a recommendation to collect and report at the national level additional data elements on rabid domestic animals, changes to the recommended man- agement of dogs and cats exposed to rabies that are ei- ther unvaccinated or overdue for booster vaccination, reduction of the recommended 6-month quarantine period for certain species, and updates to the list of marketed animal rabies vaccines. Part I. Rabies Prevention and Control A. Principles of rabies prevention and control 1. Case definition. An animal is determined to be rabid after diagnosis by a qualified laboratory as specified (see Part I. A. 10. Rabies diagnosis). The national case definition for animal rabies requires laboratory confirmation on the basis of either a positive result for the direct fluorescent antibody test (preferably performed on CNS tissue) or isola- tion of rabies virus in cell culture or a laboratory animal.10 2. Rabies virus exposure. Rabies is transmitted when the virus is introduced into bite wounds, into open cuts in skin, or onto mucous membranes from saliva or other potentially infectious material such as neural tissue.11 Questions regarding pos- sible exposures should be directed to state or local public health authorities. 3. Interdisciplinary approach. Clear and con- sistent communication and coordination among relevant animal and human health partners across and within all jurisdictions (including interna- tional, national, state, and local) is necessary to most effectively prevent and control rabies. As is the case for the prevention of many zoonotic and emerging infections, rabies prevention requires the cooperation of animal control, law enforce- ment, and natural resource personnel; veterinar- ians; diagnosticians; public health professionals; physicians; animal and pet owners; and others. An integrated program must include provisions to respond to situations; humanely re- strain, capture, and euthanize animals; administer quarantine, confinement, and observation periods; and prepare samples for submission to a testing laboratory. 4. Awareness and education. Essential compo- nents of rabies prevention and control include ongoing public education, responsible pet owner- ship, routine veterinary care and vaccination, and professional continuing education. Most animal and human exposures to rabies can be prevented by raising awareness concerning rabies transmis- sion routes, the importance of avoiding contact with wildlife, and the need for appropriate vet- erinary care. Prompt recognition and reporting of possible exposures to medical and veterinary professionals and local public health authorities are critical. 5. Human rabies prevention. Rabies in humans can be prevented by eliminating exposures to rabid animals or by providing exposed persons prompt postexposure prophylaxis consisting of local treatment of wounds in combination with appropriate administration of human rabies im- mune globulin and vaccine. An exposure assess- ment should occur before rabies postexposure prophylaxis is initiated and should include dis- cussion between medical providers and public health officials. The rationale for recommending preexposure prophylaxis and details of both pre- exposure and postexposure prophylaxis adminis- tration can be found in the current recommenda- tions of the Advisory Committee on Immunization Practices.11,12 These recommendations, along with information concerning the current local and re- gional epidemiology of animal rabies and the availability of human rabies biologics, are avail- able from state health departments. 6. Domestic animal vaccination. Multiple vac- cines are licensed for use in domestic animal spe- cies. Vaccines available include inactivated and modified-live virus vectored products, products for IM and SC administration, products with dura- tions of immunity for periods of 1 to 3 years, and products with various minimum ages of vaccina- tion. Recommended vaccination procedures are specified in Part II of this compendium; animal ra- bies vaccines licensed by the USDA and marketed in the United States are specified in Appendix 1. Local governments should initiate and maintain effective programs to ensure vaccination of all dogs, cats, and ferrets and to remove stray and un- wanted animals. Such procedures have reduced lab- oratory-confirmed cases of rabies among dogs in the United States from 6,949 cases in 1947 to 89 cases in 2013.3 Because more rabies cases are re- ported annually involving cats (247 in 2013) than dogs, vaccination of cats should be required.3 Ani- mal shelters and animal control authorities should establish policies to ensure that adopted animals are vaccinated against rabies. An important tool to optimize public and ani- mal health and enhance domestic animal rabies control is routine or emergency implementation of low-cost or free clinics for rabies vaccination. To facilitate implementation, jurisdictions should work with veterinary medical licensing boards, veterinary associations, the local veterinary com- munity, animal control officials, and animal wel- fare organizations. 7. Rabies in vaccinated animals. Rabies is rare in vaccinated animals.13–15 If rabies is suspected in a vaccinated animal, it should be reported to pub- lic health officials, the vaccine manufacturer, and the USDA APHIS Center for Veterinary Biologics ---PAGE BREAK--- JAVMA • Vol 248 • No. 5 • March 1, 2016 507 (www.aphis.usda.gov; search for “adverse event reporting”). The laboratory diagnosis should be confirmed and the virus variant characterized by the CDC’s rabies reference laboratory. A thorough epidemiologic investigation including documen- tation of the animal’s vaccination history and po- tential rabies exposures should be conducted. 8. Rabies in wildlife. It is difficult to control rabies among wildlife reservoir species.16 Vacci- nation of free-ranging wildlife or point infection control is useful in some situations,17 but the suc- cess of such procedures depends on the circum- stances surrounding each rabies outbreak (See Part I. C. Prevention and control methods related to wildlife). Because of the risk of rabies in wild animals (especially raccoons, skunks, coyotes, fox- es, and bats), the AVMA, American Public Health Association, Council of State and Territorial Epide- miologists, National Animal Care and Control As- sociation, and National Association of State Public Health Veterinarians strongly recommend the en- actment and enforcement of state laws prohibit- ing the importation, distribution, translocation, and private ownership of wild animals. 9. Rabies surveillance. Laboratory-based ra- bies surveillance and variant typing are essential components of rabies prevention and control programs. A comprehensive surveillance pro- gram should not be limited to testing only those animals that have potentially exposed people or domestic animals to rabies. Accurate and timely information and reporting are necessary to guide decisions regarding postexposure prophylaxis in potentially exposed humans, determine appro- priate management of potentially exposed ani- mals, aid in the discovery of emerging variants, describe the epidemiology of the disease, and assess the effectiveness of vaccination programs for domestic animals and wildlife. Every animal submitted for rabies testing should be reported to the CDC to evaluate surveillance trends. Public health authorities should implement electronic laboratory reporting and notification systems.18 Information reported on every animal submitted for rabies testing should include species, point location, vaccination status, rabies virus variant (if rabid), and human or domestic animal expo- sures. To enhance the ability to make evidence- based recommendations from national surveil- lance data, additional data should be collected and reported on all rabid domestic animals. In this regard, essential data elements include age, sex, neuter status, ownership status, quarantine dates (if any), date of onset of any clinical signs, and complete vaccination history. Rabid animals with a history of importation into the United States within the past 60 days are immediately notifiable by state health departments to the CDC; for all indigenous cases, standard notifica- tion protocols should be followed.19 10. Rabies diagnosis. a) The direct fluorescent antibody test is the gold standard for rabies diagnosis. The test should be performed in accordance with the established national standardized proto- col (www.cdc.gov/rabies/pdf/rabiesdfaspv2. pdf) by a qualified laboratory that has been designated by the local or state health depart- ment.20,21 Animals submitted for rabies test- ing should be euthanized22,23 in such a way as to maintain the integrity of the brain so that the laboratory can recognize anatomic struc- tures. Except in the case of very small animals, such as bats, only the head or entire brain (including brainstem) should be submitted to the laboratory. To facilitate prompt labora- tory testing, submitted specimens should be stored and shipped under refrigeration with- out delay. The need to thaw frozen specimens will delay testing. Chemical fixation of tissues should be avoided to prevent significant test- ing delays and because such fixation might preclude reliable testing. Questions about testing of fixed tissues should be directed to the local rabies laboratory or public health department. b) Rabies testing should be available out- side of normal business hours at the discre- tion of public health officials to expedite ex- posure management decisions.20 When con- firmatory testing is needed by state health departments (eg, in the event of inconclusive results, unusual species, or mass exposures), the CDC rabies laboratory can provide addi- tional testing and results within 24 hours of sample receipt.24 c) Professional associations such as the Association of Public Health Laboratories should advocate for, distribute, and promote the development of guidelines for routinely assessing testing practices within rabies labo- ratories to ensure maintenance of quality and safety. d) A direct rapid immunohistochemical test (referred to as dRIT) is being used by trained field personnel in surveillance programs for specimens not involved in human or domestic animal exposures.25–28 All positive direct rapid immunohistochemical test results need to be confirmed by means of direct fluorescent anti- body testing at a qualified laboratory. e) Currently, there are no commercially available, USDA-licensed rapid test kits for ra- bies diagnosis. Unlicensed tests should not be used owing to the following concerns: sensitiv- ity and specificity of these tests are not known, the tests have not been validated against cur- rent standard methods, the excretion of virus in the saliva is intermittent and the amount var- ies over time, any unlicensed test result would ---PAGE BREAK--- 508 JAVMA • Vol 248 • No. 5 • March 1, 2016 need to be confirmed by validated methods such as direct fluorescent antibody testing on brain tissue, and the interpretation of results from unlicensed tests may place exposed ani- mals and persons at risk. 11. Rabies serology. Some jurisdictions require evidence of vaccination and rabies virus antibod- ies for animal importation purposes. Rabies virus antibody titers are indicative of a response to vac- cine or infection. Titers do not directly correlate with protection because other immunologic fac- tors also play a role in preventing rabies and our abilities to measure and interpret those other fac- tors are not well-developed. Therefore, evidence of circulating rabies virus antibodies in animals should not be used as a substitute for current vac- cination in managing rabies exposures or deter- mining the need for booster vaccination.29–32 12. Rabies research. Information derived from well-designed studies is essential for the devel- opment of evidence-based recommendations. Data are needed in several areas, including viral shedding periods for domestic livestock and lago- morphs, potential shedding of virus in milk, the earliest age at which rabies vaccination is effec- tive, protective effect of maternal antibody, dura- tion of immunity, postexposure prophylaxis pro- tocols for domestic animals, models for treatment of clinical rabies, extralabel vaccine use in domes- tic animals and wildlife rabies reservoir species, host-pathogen adaptations and dynamics, and the ecology of wildlife rabies reservoir species, espe- cially in relation to the use of oral rabies vaccines. B. Prevention and control methods in domestic and confined animals 1. Preexposure vaccination and management. Ad- herence to a regular rabies vaccination schedule is critical to protect animals against recognized and unrecognized rabies exposures. Parenteral animal rabies vaccines should be administered only by or under the direct supervision of a licensed vet- erinarian on premises. Rabies vaccines may be administered under the supervision of a licensed veterinarian to animals held in animal shelters be- fore release.33,34 The veterinarian signing a rabies vaccination certificate must ensure that the person who administered the vaccine is identified on the certificate and has been appropriately trained in vaccine storage, handling, and administration and in the management of adverse events. This ensures that a qualified and responsible person can be held accountable for properly vaccinating the animal. Within 28 days after initial vaccination, a peak rabies virus antibody titer is expected, and the animal can be considered immunized.31,35–37 Regardless of the age of the animal at initial vac- cination, a booster vaccination should be admin- istered 1 year later (see Part II and Appendix An animal is currently vaccinated and is consid- ered immunized immediately after any booster vaccination.38,39 a) Booster vaccination. Following the ini- tial vaccination, booster vaccinations should be given in a manner consistent with the manufacturer’s label. If a previously vaccinated animal is overdue for any booster vaccination, including the first booster vaccination due 1 year after initial vaccination, it should be given a booster vaccination. Immediately after this booster vaccination, the animal is considered currently vaccinated and should be placed on a booster vaccination schedule consistent with the label of the vaccine used. There are no laboratory or epidemiological data to sup- port the annual or biennial administration of 3-year vaccines after completion of the initial vaccine series (ie, the initial vaccination and 1-year booster vaccination). b) Dogs, cats, and ferrets. All dogs, cats, and ferrets should be vaccinated against rabies and revaccinated in accordance with recommendations in this compendi- um (Appendix c) Livestock. All horses should be vac- cinated against rabies.40 Livestock, including species for which licensed vaccines are not available, that have frequent contact with humans (eg, in petting zoos, fairs, and other public exhibitions) should be vaccinated against rabies.41,42 Consideration should also be given to vaccinating livestock that are par- ticularly valuable. d) Captive wild animals and wild animal hybrids (the of wild animals cross- bred to domestic animals). Wild animals and wild animal hy- brids should not be kept as pets.43,44 No parenteral rabies vaccines are licensed for use in wild animals or wild animal hybrids.45 Animals that are farmed (eg, for food, fur, or fiber) or maintained in ex- hibits or zoological parks and that are not completely excluded from all con- tact with rabies vectors can become in- fected.46 Moreover, wild animals might be incubating rabies when initially captured. Therefore, wild-caught animals suscep- tible to rabies should be quarantined for a minimum of 6 months. Employees who work with ani- mals in exhibits or zoological parks should receive preexposure rabies vaccination. The use of preexposure or postexposure rabies vaccination for handlers who work with animals at such facilities might re- duce the need for euthanasia of captive animals that expose handlers. Carnivores and bats should be housed in a manner ---PAGE BREAK--- JAVMA • Vol 248 • No. 5 • March 1, 2016 509 that precludes direct contact with the public.41,42 Consideration may be given to vaccinating animals that are particularly valuable (see Part II. D. Vaccination of wild- life and wild animal hybrids). 2. Stray animals. Stray dogs, cats, and ferrets should be removed from the community, and mech- anisms should be put in place to facilitate voluntary surrender of animals to prevent abandonment. Lo- cal health departments and animal control officials can enforce the removal of strays more effectively if owned animals are required to have identification and be confined or kept on leash. Strays should be impounded for at least 3 business days to determine whether human exposure has occurred and to give owners sufficient time to reclaim animals. Stray and feral cats serve as a significant source of rabies exposure risk.47 If communities allow maintenance of feral cat colonies despite this risk, they should safeguard the health of the cats and the communities in which they reside by requiring that cats receive initial rabies vaccinations and ap- propriately scheduled booster vaccinations. 3. Importation and interstate movement of animals. a) Areas with dog-to-dog rabies transmis- sion. Canine rabies virus variants have been eliminated from the United States3,7; howev- er, rabid dogs and a rabid cat have been in- troduced into the continental United States from areas with dog-to-dog rabies transmis- sion.4–6,48,49 The movement of dogs for the purposes of adoption or sale from areas with dog-to-dog rabies transmission increases the risk of introducing canine-transmitted rabies to areas where it does not currently exist, and this practice should be prohibited. b) International importation. Current fed- eral regulations are insufficient to prevent the introduction of rabid animals into the United States and must be strengthened and appro- priately enforced.4–6,48,49 The CDC and USDA APHIS have regulatory authority over the importation of dogs and cats into the United States.6 Importers of dogs must comply with rabies vaccination requirements.50,51 These regulations require that dogs from rabies- endemic countries be currently vaccinated against rabies prior to importation. The appro- priate health official of the state of destination should be notified by the appropriate federal authorities within 72 hours of the arrival of any unvaccinated imported dog required to be placed in confinement (as defined by the CDC52) under these regulations. Failure of the owner to comply with these confinement re- quirements should be reported to the CDC’s Division of Global Migration and Quarantine ([EMAIL REDACTED]). All imported dogs and cats are also subject to state and local laws governing rabies and should be currently vaccinated against rabies with USDA-licensed products in accordance with this compendium. Failure of the owner to comply with state or local requirements should be referred to the appropriate state or local official. c) Interstate movement (including com- monwealths and territories). Before inter- state movement occurs, dogs, cats, ferrets, and horses should be currently vaccinated against rabies in accordance with this com- pendium. Animals in transit should be accom- panied by a current, valid rabies vaccination certificate such as Form 51 from the National Association of State Public Health Veterinar- ians.53 When an interstate health certificate or certificate of veterinary inspection is re- quired, it should contain the same rabies vac- cination information as Form 51. 4. Adjunct procedures. Methods or procedures that enhance rabies control include the following54: a) Identification. Dogs, cats, and ferrets should be identified (eg, metal or plastic tags or microchips) to allow for verification of ra- bies vaccination status. b) Licensure. Registration or licensure of all dogs, cats, and ferrets is an integral compo- nent of an effective rabies control program. A fee is frequently charged for such licensure, and revenues collected are used to maintain rabies or animal control activities. Evidence of current vaccination should be an essential prerequisite to licensure. c) Canvassing. House-to-house canvass- ing by animal control officials facilitates enforcement of vaccination and licensure requirements. d) Citations. Citations are legal summons- es issued to owners for violations, including the failure to vaccinate or license their ani- mals. The authority for officers to issue cita- tions should be an integral part of animal con- trol programs. e) Animal control. All local jurisdictions should incorporate training and continuing education of personnel regarding stray-ani- mal control, leash laws, animal bite preven- tion, and rabies prevention and control into their programs. f) Public education. All local jurisdic- tions should incorporate education covering responsible pet ownership, bite prevention, and appropriate veterinary care into their programs. 5. Postexposure management. This section re- fers to any animal exposed (see Part I. A. 2. Rabies virus exposure) to a confirmed or suspected ra- bid animal. Wild mammalian carnivores, skunks, and bats that are not available or suitable for test- ing should be regarded as rabid. The rationale for ---PAGE BREAK--- 510 JAVMA • Vol 248 • No. 5 • March 1, 2016 observation, confinement, or strict quarantine periods of exposed animals despite previous vac- cination is based in part on the potential for over- whelming viral challenge, incomplete vaccine ef- ficacy, improper vaccine administration, variable host immunocompetence, and immune-mediated death (ie, early death phenomenon).13,55–57 a) Dogs, cats, and ferrets. Any illness in an exposed animal should be reported immedi- ately to the local health department. If signs suggestive of rabies develop (eg, paralysis or seizures), the animal should be euthanized, and the head or entire brain (including brain- stem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis). Dogs, cats, and ferrets that are current on rabies vaccination should im- mediately receive veterinary medical care for assessment, wound cleansing, and booster vaccination. The animal should be kept under the owner’s control and observed for 45 days. Dogs, cats, and ferrets that have never been vaccinated should be eutha- nized immediately. There are currently no USDA-licensed biologics for postex- posure prophylaxis of previously unvac- cinated domestic animals, and there is evidence that the use of vaccine alone will not reliably prevent the disease in these animals.58 If the owner is unwilling to have the animal euthanized, the animal should be placed in strict quarantine for 4 (dogs and cats) or 6 (ferrets) months. Strict quarantine in this context refers to confinement in an enclosure that pre- cludes direct contact with people and other animals. A rabies vaccine should be administered at the time of entry into quarantine to bring the animal up to cur- rent rabies vaccination status. Administra- tion of vaccine should be done as soon as possible. It is recommended that the period from exposure to vaccination not exceed 96 hours.59,60 If vaccination is de- layed, public health officials may consider increasing the quarantine period for dogs and cats from 4 to 6 months, taking into consideration factors such as the severity of exposure, the length of delay in vac- cination, current health status, and local rabies epidemiology. Dogs and cats that are overdue for a booster vaccination and that have appro- priate documentation of having received a USDA-licensed rabies vaccine at least once previously should immediately receive veterinary medical care for assessment, wound cleansing, and booster vaccination. The animal should be kept under the own- er’s control and observed for 45 days.39 If booster vaccination is delayed, public health officials may consider increasing the observation period for the animal, tak- ing into consideration factors such as the severity of exposure, the length of delay in booster vaccination, current health status, and local rabies epidemiology. Dogs and cats that are overdue for a booster vaccination and without appropriate documentation of having received a USDA-licensed rabies vaccine at least once previously should imme- diately receive veterinary medical care for assessment, wound cleansing, and consultation with local public health authorities. The animal can be treated as unvaccinated, immediately given a booster vaccination, and placed in strict quarantine (see Part I. B. 5. a) Alternatively, prior to booster vaccination, the attending veterinar- ian may request guidance from the local public health authorities in the possible use of prospective se- rologic monitoring. Such monitoring would entail collecting paired blood samples to document prior vacci- nation by providing evidence of an anamnestic response to booster vac- cination. If an adequate anamnestic response is documented, the animal can be considered to be overdue for booster vaccination (see Part I. B. 5. a) and observed for 45 days.39 If there is inadequate evidence of an anamnestic response, the animal is considered to have never been vacci- nated and should be placed in strict quarantine (see Part I. B. 5. a) Ferrets that are overdue for a booster vaccination should be evalu- ated on a case-by-case basis, taking into consideration factors such as the sever- ity of exposure, time elapsed since last vaccination, number of previous vacci- nations, current health status, and local rabies epidemiology, to determine need for euthanasia or immediate booster vac- cination followed by observation or strict quarantine. b) Livestock. All species of livestock are susceptible to rabies; cattle and horses are the most frequently reported infected species.3 Any illness in an exposed animal should be re- ported immediately to the local health depart- ment and animal health officials. If signs sug- gestive of rabies develop, the animal should be euthanized, and the head or entire brain ---PAGE BREAK--- JAVMA • Vol 248 • No. 5 • March 1, 2016 511 (including brainstem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis). Livestock that have never been vaccinated should be euthanized imme- diately. Animals that are not euthanized should be confined and observed on a case-by-case basis for 6 months. Livestock that are current on ra- bies vaccination with a USDA-licensed vaccine approved for that species should be given a booster vaccination immedi- ately and observed for 45 days. Livestock overdue for a booster vaccination should be evaluated on a case-by-case basis, taking into consider- ation factors such as severity of expo- sure, time elapsed since last vaccination, number of previous vaccinations, current health status, and local rabies epidemiol- ogy, to determine need for euthanasia or immediate booster vaccination followed by observation or strict quarantine. Multiple rabid animals in a herd and herbivore-to-herbivore transmission of rabies are uncommon.61 Therefore, restrict- ing the rest of the herd if a single animal has been exposed to or infected with rabies is usually not necessary. Rabies virus is widely distributed in the tissues of rabid animals.62–64 Tissues and products from a rabid animal should not be used for human or animal consumption65,66 or transplantation.67 However, pasteuriza- tion and cooking will inactivate rabies vi- rus.68 Therefore, inadvertently drinking pas- teurized milk or eating thoroughly cooked animal products does not constitute a ra- bies exposure. Handling and consumption of uncooked tissues from exposed animals might carry a risk for rabies transmis- sion.69 Persons handling exposed animals, carcasses, and tissues should use appro- priate barrier precautions.69,70 State and local public health authorities, state meat inspectors, and the USDA Food Safety and Inspection Service should be notified if exposures occur in animals intended for commercial use. Animals should not be presented for slaughter in a USDA-regu- lated establishment if such animals origi- nate from a quarantine area and have not been approved for release by the proper authority. If an exposed animal is to be custom slaughtered or home slaughtered for consumption, it should be slaugh- tered immediately after exposure, and all tissues should be cooked thoroughly. c) Other animals. Other mammals ex- posed to a rabid animal should be euthanized immediately. Animals maintained in USDA- licensed research facilities or accredited zoo- logical parks should be evaluated on a case-by- case basis in consultation with public health authorities. Management options may include quarantine, observation, or administration of rabies biologics. 6. Management of animals that bite humans. a) Dogs, cats, and ferrets. Rabies virus is excreted in the saliva of infected dogs, cats, and ferrets during illness and for only a few days before the onset of clinical signs or death.71–73 Regardless of rabies vaccination status, a healthy dog, cat, or ferret that expos- es a person should be confined and observed daily for 10 days from the time of the expo- sure74; administration of rabies vaccine to the animal is not recommended during the ob- servation period to avoid confusing signs of rabies with rare adverse vaccine reactions.15 Any illness in the animal should be reported immediately to the local health department. Such animals should be evaluated by a veteri- narian at the first sign of illness during con- finement. If signs suggestive of rabies devel- op, the animal should be euthanized, and the head or entire brain (including brainstem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis). Any stray or unwanted dog, cat, or ferret that exposes a person may be euthanized immediately, and the head or entire brain (including brainstem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis). b) Other animals. Other animals that might have exposed a person to rabies should be reported immediately to the local health department. Management of animals other than dogs, cats, and ferrets depends on the species, the circumstances of the expo- sure, the epidemiology of rabies in the area, the exposing animal’s history and current health status, and the animal’s potential for exposure to rabies. The shedding period for rabies virus is undetermined for most spe- cies. Previous vaccination of these animals might not preclude the necessity for eutha- nasia and testing. 7. Outbreak prevention and control. The emer- gence of new rabies virus variants or the introduc- tion of nonindigenous viruses poses a significant risk to humans, domestic animals, and wildlife.75–82 A rapid and comprehensive response involves coordination of multiple agencies (see Part I. A. 3. Interdisciplinary approach) to accomplish the fol- lowing outcomes83: • Characterize the virus at the national refer- ence laboratory. • Identify and control the source of the introduction. ---PAGE BREAK--- 512 JAVMA • Vol 248 • No. 5 • March 1, 2016 • Enhance laboratory-based surveillance in wild and domestic animals. • Increase animal rabies vaccination rates. • Restrict the movement of animals. • Evaluate the need for wildlife intervention activities (eg, point infection control, trap- vaccinate-release programs, and oral rabies vaccination programs). • Provide public and professional outreach and education. 8. Disaster response. Animals might be dis- placed during and after man-made or natural disas- ters and require emergency sheltering.84–86 Animal rabies vaccination and exposure histories are often not available for displaced animals, and disaster re- sponse can create situations where animal caretak- ers might lack appropriate training or preexposure vaccination. In such situations, it is critical to imple- ment and coordinate rabies prevention and control measures to reduce the risk of rabies transmission and the need for human postexposure prophylaxis. Such measures include the following actions: • Coordinate relief efforts of individuals and or- ganizations with the local emergency opera- tions center before deployment. • Examine each animal at a triage site for pos- sible bite injuries or signs of rabies. • Isolate animals exhibiting signs of rabies pending evaluation by a veterinarian. • Ensure that all animals have a unique identifier. • Administer a rabies vaccine to all dogs, cats, and ferrets unless reliable proof of current vaccination exists. • Adopt minimum standards for animal caretak- ers as feasible, including use of personal protec- tive equipment, completion of the preexposure rabies vaccination series prior to deployment, and provision of appropriate training.87 • Maintain documentation of animal disposi- tion and location (eg, returned to owner, died or euthanized, adopted, or relocated to anoth- er shelter with address of new location). • Provide facilities to confine and observe ani- mals involved in exposures (see Part I. B. 6. Management of animals that bite humans). • Report human exposures to appropriate pub- lic health authorities (see Part I. A. 2. Rabies virus exposure). C. Prevention and control methods related to wildlife The public should be warned not to handle or feed wild mammals. Wild mammals and wild animal hybrids that expose persons, pets, or livestock should be considered for euthanasia and rabies testing. A per- son exposed by any wild mammal should immediately wash the wound thoroughly and report the incident to a health-care provider who, in consultation with public health authorities, can evaluate the need for postexposure prophylaxis.11,12 Translocating infected wildlife has contributed to the spread of rabies,75–80,88 and animals that appear healthy can still be rabid. Therefore, translocation (ie, moving live animals from their point of capture and releasing them) of known rabies reservoir species should be prohibited.89 Whereas state-regulated wild- life rehabilitators and nuisance-wildlife control opera- tors should play a role in a comprehensive rabies con- trol program, minimum standards for these persons who handle wild mammals should include rabies pre- exposure vaccination, specific rabies prevention and control training, and ongoing continuing education. 1. Carnivores. The use of oral rabies vaccines for mass vaccination of free-ranging wildlife should be considered in selected situations, with the approval of appropriate state and local agencies.16,90 There have been documented successes using oral rabies vaccines to control rabies in wildlife in North Amer- ica.90–93 The currently licensed vaccinia-vectored oral rabies vaccine is labeled for use in raccoons and coy- otes. Research to improve existing oral rabies vaccine and baits and to develop and test novel products to determine safety and efficacy must be encouraged. The distribution of oral rabies vaccines should be based on scientific assessments of the target species and followed by timely and appropriate analysis of surveillance data, with results provided to all stake- holders. In addition, parenteral vaccination (trap-vac- cinate-release) of wildlife rabies reservoir species may be integrated into coordinated oral rabies vaccine programs to enhance their effectiveness. Continuous and persistent programs for trapping or poisoning wildlife are not effective in reducing populations of wildlife rabies reservoir species on a statewide basis. However, limited population control in high-contact areas (eg, picnic grounds, camps, and suburban areas) might be indicated for the removal of selected high- risk species of wildlife. State agriculture, public health, and wildlife agencies should be consulted for plan- ning, coordination, and evaluation of vaccination or point infection control programs.16 2. Bats. From the 1950s to today, indigenous rabid bats have been reported from every state except Ha- waii and have caused rabies in at least 54 humans in the United States.94–103 Bats should be excluded, using appropriate methods, from houses, public buildings, and adjacent structures to prevent direct association with humans.104,105 Such structures should then be made bat-proof by sealing entrances used by bats. Con- trolling rabies in bats through programs designed to reduce bat populations is neither feasible nor desirable. Part II. Recommendations for Parenteral Rabies Vaccination Procedures A. Vaccine administration All animal rabies vaccines should be restricted to use by or under the direct supervision of a veterinar- ---PAGE BREAK--- JAVMA • Vol 248 • No. 5 • March 1, 2016 513 ian,106 except as recommended otherwise (see Part I. B. 1. Preexposure vaccination and management). B. Vaccine selection All vaccines licensed by the USDA and marketed in the United States at the time of publication of this compendium are listed (Appendix Newly approved vaccines and changes in label specifications made sub- sequent to publication should be considered as part of this list. Any of the listed vaccines can be used for revaccination, even if the product is not the same as the one previously administered. Vaccines used in state and local rabies control programs should have at least a 3-year duration of immunity. This constitutes the most effective method of increasing the propor- tion of immunized dogs and cats in any population.107 C. Adverse events Currently, no epidemiological association exists between any particular licensed vaccine product and adverse events.15,34,108–110 Although rare, adverse events such as vomiting, injection site swelling, leth- argy, hypersensitivity, and the occurrence of rabies despite previous vaccination of an animal have been reported. Adverse events should be reported to the vaccine manufacturer and to USDA APHIS’s Center for Veterinary Biologics (www.aphis.usda.gov; search for “adverse event reporting”). Although ill animals may not have a full immunologic response to vac- cination, there is no evidence to suggest that adverse events are more likely to occur with rabies vaccina- tion of ill than healthy animals. A veterinarian choos- ing to temporarily delay vaccinating an animal with an acute illness or condition should ensure that the animal is vaccinated as soon as possible. Animals with a previous history of anaphylaxis can be medically managed and observed after vaccination.56 Severe adverse events related to rabies vaccination are ex- tremely rare in animals. Decisions concerning rabies vaccination of animals with well-documented severe adverse events to rabies vaccine must be made with- in the context of a valid veterinarian-client-patient relationship. Due consideration should be given to the attendant risks and benefits of not vaccinating, in- cluding regulatory noncompliance. Animals not cur- rently vaccinated that experience a rabies exposure are at greater risk for infection and death and also put their owners and the community at risk. D. Vaccination of wildlife and wild animal hybrids The safety and efficacy of parenteral rabies vac- cines in wildlife and wild animal hybrids have not been established, and no rabies vaccines are currently li- censed for use in these animals. Thus, any use of rabies vaccines in these animals is considered extralabel use. Zoos or research institutions may establish vaccination programs in an attempt to protect valuable animals, but these should not replace appropriate public health activities that protect humans (see Part I. B. 1. d) E. Accidental human exposure to rabies vaccines Human exposure to parenteral animal rabies vac- cines listed in Appendix 1 does not constitute a risk for rabies virus infection. Human exposure to vaccinia- vectored oral rabies vaccines should be reported to state health officials.111,112 F. Rabies certificates All agencies and veterinarians should use Form 51, the rabies vaccination certificate recommended by the National Association of State Public Health Veterinar- ians,53 or should use an equivalent. The form must be completed in full and signed by the administering or supervising veterinarian. Computer-generated forms containing the same information are also acceptable. References 1. Rabies. In: Heymann D, ed. Control of communicable diseases manual. 20th ed. Washington, DC: American Public Health As- sociation, 2015;497–508. 2. International Committee on Taxonomy of Viruses. Virus tax- onomy: 2014 release. Order Mononegavirales: family Rhabdo- viridae: genus Lyssavirus. 2014. Available at: www.ictvonline. org/virusTaxonomy.asp. Accessed Jun 15, 2015. 3. Dyer JL, Yager P, Orciari L, et al. Rabies surveillance in the Unit- ed States during 2013. J Am Vet Med Assoc 2014;245:1111– 1123. 4. Castrodale L, Walker V, Baldwin J, et al. Rabies in a puppy im- ported from India to the USA, March 2007. Zoonoses Public Health 2008;55:427–430. 5. CDC. Rabies in a dog imported from Iraq—New Jersey, June 2008. MMWR Morb Mortal Wkly Rep 2008;57:1076–1078. 6. McQuiston JH, Wilson T, Harris S, et al. Importation of dogs into the United States: risks from rabies and other zoonotic diseas- es. Zoonoses Public Health 2008;55:421–426. 7. Velasco-Villa A, Reeder SA, Orciari LA, et al. Enzootic rabies elimination from dogs and reemergence in wild terrestrial carnivores, United States. Emerg Infect Dis 2008;14:1849– 1854. 8. Beran GW. Rabies and infections by rabies-related viruses. In: Beran GW, ed. Handbook of zoonoses section B: viral. 2nd ed. Boca Raton, Fla: CRC Press, 1994;307–357. 9. Brown CM, Conti L, Ettestad P, et al. Compendium of animal rabies prevention and control, 2011. J Am Vet Med Assoc 2011;239;609–617. 10. Council of State and Territorial Epidemiologists Infectious Dis- ease Subcommittee. Public health reporting and national no- tification for animal rabies. 09-ID-12. Atlanta: Council of State and Territorial Epidemiologists, 2009. Available at: com/sites/www.cste.org/resource/resmgr/PS/09-ID-12.pdf. Accessed Jun 15, 2015. 11. Manning SE, Rupprecht CE, Fishbein D, et al. Human rabies pre- vention—United States, 2008. Recommendations of the Advi- sory Committee on Immunization Practices. MMWR Recomm Rep 2008;57(RR-3):1–28. 12. Rupprecht CE, Briggs D, Brown CM, et al. Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies. Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 2010;59(RR-2):1–9. 13. McQuiston JH, Yager PA, Smith JS, et al. Epidemiologic char- acteristics of rabies virus variants in dogs and cats in the United States, 1999. J Am Vet Med Assoc 2001;218:1939– 1942. 14. Murray KO, Holmes KC, Hanlon CA. Rabies in vaccinated dogs and cats in the United States, 1997–2001. J Am Vet Med Assoc 2009;235:691–695. ---PAGE BREAK--- 514 JAVMA • Vol 248 • No. 5 • March 1, 2016 15. Frana TS, Clough NE, Gatewood DM, et al. Postmarketing sur- veillance of rabies vaccines for dogs to evaluate safety and ef- ficacy. J Am Vet Med Assoc 2008;232:1000–1002. 16. Hanlon CA, Childs JE, Nettles VF, et al. Recommendations of a national working group on prevention and control of rabies in the United States. Article III: rabies in wildlife. 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MMWR Morb Mortal Wkly Rep 2009;58:1204–1207. ---PAGE BREAK--- 516 JAVMA • Vol 248 • No. 5 • March 1, 2016 Age at primary Route of Product name Produced by Marketed by For use in Dose vaccination* Booster vaccination inoculation Monovalent (inactivated) RABVAC 1 Boehringer Ingelheim Vetmedica Inc License No. 124 Boehringer Ingelheim Vetmedica Inc Dogs and cats 1 mL 3 mo Annually IM or SC RABVAC 3 Boehringer Ingelheim Vetmedica Inc License No. 124 Boehringer Ingelheim Vetmedica Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Horses 2 mL 3 mo Annually IM EQUI-RAB with Havlogen Merck Animal Health License No. 165A Merck Animal Health Horses 1 mL 4 mo Annually IM DEFENSOR 1 Zoetis License No. 190 Zoetis Dogs 1 mL 3 mo Annually IM or SC Cats 1 mL 3 mo Annually SC DEFENSOR 3 Zoetis License No. 190 Zoetis Dogs 1 mL 3 mo 1 year later and triennially IM or SC Cats 1 mL 3 mo 1 year later and triennially SC Sheep and cattle 2 mL 3 mo Annually IM NOBIVAC: 1-Rabies Zoetis License No. 190 Merck Animal Health Dogs 1 mL 3 mo Annually IM or SC Cats 1 mL 3 mo Annually SC NOBIVAC: 3-Rabies and Zoetis License No. 190 Merck Animal Health Dogs 1 mL 3 mo 1 year later and triennially IM or SC 3-Rabies CA Cats 1 mL 3 mo 1 year later and triennially SC Sheep and cattle 2 mL 3 mo Annually IM IMRAB 1 Merial Inc License No. 298 Merial Inc Dogs and cats 1 mL 3 mo Annually SC IMRAB 1 TF Merial Inc License No. 298 Merial Inc Dogs and cats 1 mL 3 mo Annually SC IMRAB 3 Merial Inc License No. 298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Sheep 2 mL 3 mo 1 year later and triennially IM or SC Cattle and horses 2 mL 3 mo Annually IM or SC Ferrets 1 mL 3 mo Annually SC IMRAB 3 TF Merial Inc License No. 298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Ferrets 1 mL 3 mo Annually SC IMRAB Large Animal Merial Inc License No. 298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Cattle and horses 2 mL 3 mo Annually IM or SC Sheep 2 mL 3 mo 1 year later and triennially IM or SC Monovalent (rabies glycoprotein; live canary pox vector) PUREVAX Feline Rabies Merial Inc License No. 298 Merial Inc Cats 1 mL 3 mo Annually SC PUREVAX Feline Merial Inc License No. 298 Merial Inc Cats 1 mL 3 mo 1 year later and triennially SC Rabies 3 YR Combination (inactivated) Equine POTOMAVAC + Merial Inc License No. 298 Merial Inc Horses 1 mL 3 mo Annually IM IMRAB Combination (rabies glycoprotein; live canary pox vector) PUREVAX Feline 3/Rabies Merial Inc License No. 298 Merial Inc Cats 1 mL 8 wk Every 3 to 4 wk until 3 mo SC and annually 3 mo 3 to 4 wk later and annually SC PUREVAX Feline 4/Rabies Merial Inc License No. 298 Merial Inc Cats 1 mL 8 wk Every 3 to 4 wk until 3 mo SC and annually 3 mo 3 to 4 wk later and annually SC Oral (rabies glycoprotein; live vaccinia vector)† RABORAL V-RG Merial Inc License No. 298 Merial Inc Raccoons and coyotes NA NA As determined by local Oral authorities *One month = 28 days. †Oral rabies vaccines are restricted for use in federal and state rabies control programs. NA = Not applicable. Information is provided by the vaccine manufacturers and USDA APHIS’s Center for Veterinary Biologics and is subject to change. Appendix 1 Rabies vaccines licensed and marketed in the United States, 2016. ---PAGE BREAK--- JAVMA • Vol 248 • No. 5 • March 1, 2016 517 Appendix 2 Rabies vaccine manufacturer contact information Manufacturer Phone No. URL Boehringer Ingelheim Vetmedica Inc 800–638–2226 www.bi-vetmedica.com Merck Animal Health Inc 800–521–5767 www.merck-animal-health-usa.com Merial Inc 888–637–4251 us.merial.com Zoetis 800–366–5288 www.zoetis.com